UC0006
SMILES: C(OC(NC(Cc1cc(c(cc1)O)O)C(=O)O)=O)(C)(C)C
NAME: 2-[(tert-butoxycarbonyl)amino]-3-(3,4-dihydroxyphenyl)propanoic acid
CAS: 102838-86-8 (as dicyclopropylamine salt)
Sigma-Aldrich: not found
ChemImpex: $59.40/250mg
The phenolic hydroxyl groups must be protected during peptide synthesis:
-with TBDMS (a silyl protecting group) in Tetrahedron, 2001, 57, 6139.
-with Methyl J. Med. Chem. 1987, 16, 3081.
-with Benzyl J. Chem. Soc. Perkin I, 1987, 3, 613.
1 Comments:
This is not found in any of the Malaria37 100 molecules in regards as an acid in the Ugi synthesis.
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